Activated coagulation factor X: a novel mitogenic stimulus for human mesangial cells.

@article{Monno2001ActivatedCF,
  title={Activated coagulation factor X: a novel mitogenic stimulus for human mesangial cells.},
  author={Raffaella Monno and Giuseppe Grandaliano and Roberta Faccio and Elena Ranieri and Carmela Di Martino and Loreto Gesualdo and Francesco Paolo Schena},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 5},
  pages={891-9}
}
Intraglomerular activation of the coagulation cascade is a common feature of mesangioproliferative glomerulonephritis. Besides thrombin, very little is known about the cellular effects of other components of the coagulation system. This study investigated the effect of activated factor X (FXa) on cultured human mesangial cells. This serine protease induced a significant and dose-dependent increase in DNA synthesis. In addition to its mitogenic effect, FXa caused a striking upregulation of… CONTINUE READING

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