Activated cholinergic signaling provides a target in squamous cell lung carcinoma.

  title={Activated cholinergic signaling provides a target in squamous cell lung carcinoma.},
  author={Pingfang Song and Harmanjatinder S. Sekhon and Xiao Fu and Michelle A Maier and Yibing Jia and Jie Duan and Becky J. Proskosil and Courtney A. Gravett and J. C. Lindstrom and Gregory P. Mark and Saurabh Saha and E. R. Spindel},
  journal={Cancer research},
  volume={68 12},
The binding of exogenous nicotine to nicotinic acetylcholine (ACh) receptors (nAChR) and the binding of endogenous ACh to both nAChR and muscarinic ACh receptors (mAChR) stimulate growth of both small cell and non-small cell lung carcinomas. Understanding how cholinergic signaling is up-regulated in lung cancer may suggest new therapeutic approaches. Analysis of 28 squamous cell lung carcinomas (SCC) showed increased levels of alpha5 and beta3 nAChR mRNA and increased levels of ACh associated… CONTINUE READING


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