Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.

@article{Su2001ActivatedCE,
  title={Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.},
  author={Joseph H. Su and Mingming Zhao and Aileen J Anderson and Anu Srinivasan and Carl Cotman},
  journal={Brain research},
  year={2001},
  volume={898 2},
  pages={350-7}
}
Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may… CONTINUE READING

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