Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway.

@article{Fassler1997ActivatedAO,
  title={Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway.},
  author={Jan S. Fassler and William M Gray and Cheryl Malone and Wei Tao and H M Lin and Robert J. Deschenes},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 20},
  pages={13365-71}
}
Two-component signal transduction systems involving histidine autophosphorylation and phosphotransfer to an aspartate residue on a receiver molecule have only recently been discovered in eukaryotes, although they are well studied in prokaryotes. The Sln1 protein of Saccharomyces cerevisiae is a two-component regulator involved in osmotolerance. Phosphorylation of Sln1p leads to inhibition of the Hog1 mitogen-activated protein kinase osmosensing pathway. We have discovered a second function of… CONTINUE READING
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