Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

@article{Whiteman2009ActivatedAF,
  title={Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.},
  author={Ineka Therese Whiteman and Othon L. Gervasio and Karen M. Cullen and Gilles J Guillemin and Erica V Jeong and Paul K Witting and Shane Tony Antao and Laurie S. Minamide and James R. Bamburg and Claire S Goldsbury},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 41},
  pages={
          12994-3005
        }
}
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence correlates with cognitive decline and disease progression. The assembly mechanism of these respective pathological lesions and the relationship between them is poorly understood, yet vital to understanding the causes of sporadic AD. We demonstrate that… CONTINUE READING

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