Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.

@article{Chien2009ActivatedWS,
  title={Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.},
  author={Andy J. Chien and Erin C Moore and Anke S. Lonsdorf and Rima M. Kulikauskas and Bonnie E. Gould Rothberg and Aaron J. Berger and Michael B. Major and Sam Hwang and David L. Rimm and Randall T. Moon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 4},
  pages={1193-8}
}
This study demonstrates that in malignant melanoma, elevated levels of nuclear beta-catenin in both primary tumors and metastases correlate with reduced expression of a marker of proliferation and with improved survival, in contrast to colorectal cancer. The reduction in proliferation observed in vivo is recapitulated in B16 murine melanoma cells and in human melanoma cell lines cultured in vitro with either WNT3A or small-molecule activators of beta-catenin signaling. Consistent with these… CONTINUE READING
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