Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.

  title={Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.},
  author={U Shu and Mamoru Kiniwa and Chong Yang Wu and Charlie Maliszewski and Nadia Vezzio and Jalil Hakimi and Maurice Gately and Guy J. Delespesse},
  journal={European journal of immunology},
  volume={25 4},
Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with… CONTINUE READING

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