Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells.

@article{Hegyi2012ActivatedTA,
  title={Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells.},
  author={Be{\'a}ta Hegyi and Gy{\"o}ngyi Kudlik and Eva Monostori and Ferenc Uher},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={419 2},
  pages={215-20}
}
In recent years it has become clear that mesenchymal stem or stromal cells (MSCs) are capable of modulating inflammatory and immune responses through interaction with a wide variety of cells. Whereas several studies indicated that PGE2 is one of the chief soluble mediators involved in these processes, here we investigated prostaglandin E2 (PGE2) production of murine bone marrow- (BM-) and adipose tissue- (Ad-) derived MSCs stimulated with pro-inflammatory cytokines TNF-α and IFN-γ, or co… CONTINUE READING