Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia.

@article{Jiang2008ActivatedSK,
  title={Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia.},
  author={Xiangning Jiang and Dezhi Mu and Valerie Biran and Joel V Faustino and Shengjun Chang and Christina M Rinc{\'o}n and R. Ann Sheldon and D M Ferriero},
  journal={Annals of neurology},
  year={2008},
  volume={63 5},
  pages={632-41}
}
OBJECTIVE Neonatal stroke is associated with the N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxic brain injury. Src family kinases (SFKs) are considered to be the molecular hub for NMDAR regulation. We determined the relationship between SFKs activation and NMDAR tyrosine phosphorylation after neonatal hypoxia-ischemia (HI) and investigated the neuroprotective potential of a selective SFKs inhibitor, PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo [3, 4-d] pyramidine), against… CONTINUE READING
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