Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats.

@article{Gratzke2010ActivatedRK,
  title={Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats.},
  author={Christian Gratzke and Travis D Strong and Milena A Gebska and Hunter C. Champion and Christian G Stief and Arthur L. Burnett and Trinity J. Bivalacqua},
  journal={The Journal of urology},
  year={2010},
  volume={184 5},
  pages={2197-204}
}
PURPOSE RhoA and rho kinase serve as key regulators of penile vascular homeostasis. The role of RhoA/rho kinase signaling in the penis after cavernous nerve injury has not been fully investigated. We characterized the molecular expression profiles of RhoA/rho kinase signaling that occur in the penis after cavernous nerve injury. We hypothesized that erectile dysfunction after bilateral cavernous nerve injury is accompanied by up-regulation of RhoA/rho kinase activity in the rat penis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction

International braz j urol : official journal of the Brazilian Society of Urology • 2017
View 4 Excerpts
Highly Influenced

Erectile dysfunction

Nature Reviews Disease Primers • 2016

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Effect of cavernous neurotomy on corpus cavernosum smooth muscle: alteration in myosin isoform composition and the sphingosine-1-phosphate/rho-kinase signaling pathway

M Aydin, R Chua, X Zhang
J Urol • 2009

Cavernous nerve injury using rodent animal models.

The journal of sexual medicine • 2008
View 5 Excerpts

Penile rehabilitation following radical prostatectomy.

Current opinion in urology • 2008
View 3 Excerpts

Similar Papers

Loading similar papers…