Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats.

  title={Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats.},
  author={Christian Gratzke and Travis D Strong and Milena A Gebska and Hunter C. Champion and Christian G Stief and Arthur L. Burnett and Trinity J. Bivalacqua},
  journal={The Journal of urology},
  volume={184 5},
PURPOSE RhoA and rho kinase serve as key regulators of penile vascular homeostasis. The role of RhoA/rho kinase signaling in the penis after cavernous nerve injury has not been fully investigated. We characterized the molecular expression profiles of RhoA/rho kinase signaling that occur in the penis after cavernous nerve injury. We hypothesized that erectile dysfunction after bilateral cavernous nerve injury is accompanied by up-regulation of RhoA/rho kinase activity in the rat penis… CONTINUE READING


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