Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration

@inproceedings{Curcio2017ActivatedRP,
  title={Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration},
  author={Christine A. Curcio and Emma C. Zanzottera and Thomas Ach and Chandrakumar Balaratnasingam and K Bailey Freund},
  booktitle={Investigative ophthalmology & visual science},
  year={2017}
}
Purpose To summarize and contextualize recent histology and clinical imaging publications on retinal pigment epithelium (RPE) fate in advanced age-related macular degeneration (AMD); to support RPE activation and migration as important precursors to atrophy, manifest as intraretinal hyperreflective foci in spectral-domain optical coherence tomography (SDOCT). Methods The Project MACULA online resource for AMD histopathology was surveyed systematically to form a catalog of 15 phenotypes of RPE… CONTINUE READING