Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification

@article{Hanashiro2011ActivatedRI,
  title={Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification},
  author={Kazuhiko Hanashiro and Mara Brancaccio and Kenji Fukasawa},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={2188-2197}
}
Initiation of centrosome duplication and DNA replication is coupled, which is primarily achieved by the late G1 phase-specific activation of cyclin-dependent kinase 2 (CDK2)-cyclin E, which triggers both centrosome duplication and DNA replication. Uncoupling of these two events contributes to overduplication of centrosomes, resulting in the presence of more than two centrosomes (centrosome amplification). Centrosome amplification, which is frequently observed in cancers, contributes to tumor… CONTINUE READING

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Oncogenes and tumour suppressors take on centrosomes

Nature Reviews Cancer • 2007
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