Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.

@article{Chen2005ActivatedNC,
  title={Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.},
  author={Yi-Guang Chen and Caroline-Morgane Choisy-Rossi and T. Matthew Holl and Harold D. Chapman and Gurdyal S Besra and Steven A. Porcelli and Daniel J. Shaffer and Derry Charles Roopenian and Sandy Wilson and David V Serreze},
  journal={Journal of immunology},
  year={2005},
  volume={174 3},
  pages={1196-204}
}
NKT cell activation by alpha-galactosylceramide (alpha-GalCer) inhibits autoimmune diabetes in NOD mice, in part by inducing recruitment to pancreatic lymph nodes (PLNs) of mature dendritic cells (DCs) with disease-protective effects. However, how activated NKT cells promote DC maturation, and what downstream effect this has on diabetogenic T cells was unknown. Activated NKT cells were found to produce a soluble factor(s) inducing DC maturation. Initially, there was a preferential accumulation… CONTINUE READING