Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism

@inproceedings{Li2012ActivatedMN,
  title={Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism},
  author={Ang Li and Yafeng Ma and Meng Jin and Susan G. Mason and Richard Lester Mort and Karen Blyth and Lionel Larue and Owen James Sansom and Laura M Machesky},
  booktitle={The Journal of investigative dermatology},
  year={2012}
}
Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation. NRas signals downstream of the major melanocyte tyrosine kinase receptor c-kit and activated NRas results in increased signaling via the extracellular signal-regulated kinase (ERK)/MAPK/ERK kinase/mitogen-activated protein kinase (MAPK) pathways to enhance proliferation. The Ras oncogene also activates signaling via the related Rho… CONTINUE READING
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