Activated MHC-mismatched T helper-1 lymphocyte infusion enhances GvL with limited GvHD

@article{Zeng2014ActivatedMT,
  title={Activated MHC-mismatched T helper-1 lymphocyte infusion enhances GvL with limited GvHD},
  author={Yi Zeng and Jessica M Stokes and Seongmin Hahn and Eric P. Hoffman and Emmanuel Katsanis},
  journal={Bone Marrow Transplantation},
  year={2014},
  volume={49},
  pages={1076-1083}
}
DLI is traditionally used to provide graft-versus-leukemia (GvL) effects when given to patients relapsing post-hematopoietic cell transplantation (HCT). However, it is often associated with significant GvHD and has only modest efficacy against acute leukemias. Therefore, novel cellular therapies are needed to improve the outcome of high-risk or relapsed… CONTINUE READING