Activated M-phase-promoting factor (MPF) is exported from the nucleus of starfish oocytes to increase the sensitivity of the Ins(1,4,5)P3 receptors.

@article{Santella2003ActivatedMF,
  title={Activated M-phase-promoting factor (MPF) is exported from the nucleus of starfish oocytes to increase the sensitivity of the Ins(1,4,5)P3 receptors.},
  author={Luigia Santella and Emanuela Ercolano and Dong-Gyun Lim and Gilda A Nusco and Francesco Moccia},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 1},
  pages={
          79-82
        }
}
Starfish oocytes that are extracted from the ovaries are arrested at the prophase of the first meiotic division. At this stage of maturation, they are characterized by a large nucleus called the germinal vesicle. Meiosis resumption (maturation) can be induced in vitro by adding the hormone 1-methyladenine (1-MA) to the seawater in which the oocytes are suspended. Earlier work in our laboratory had detected Ca(2+) increases in both the cytoplasm and the nucleus of the oocytes approx. 2 min after… CONTINUE READING