Activated Leukocyte Cell Adhesion Molecule (ALCAM) Expression is Associated with a Poor Prognosis for Bladder Cancer Patients

@inproceedings{Tomita2003ActivatedLC,
  title={Activated Leukocyte Cell Adhesion Molecule (ALCAM) Expression is Associated with a Poor Prognosis for Bladder Cancer Patients},
  author={Kyoichi Tomita and Adrie van Bokhoven and K Jansen and Lambertus A Kiemeney and Herbert F. M. Karthaus and J.L.J. Vriesema and Marion J. G. Bussemakers and Johannes Alfred Witjes and Jack A Schalken},
  year={2003}
}
Objectives: Functional E-cadherin adhesion complexes are necessary to maintain the normal differentiated phenotype in bladder epithelial cells and dysfunction of molecules in this complex is associated with an invasive phenotype. Moreover, loss of functioning of E-cadherin and/or α-catenin in cancer cells is associated with a poor prognosis for bladder cancer patients. Clearly, other adhesion molecules are also involved in the process of invasion and/or metastasis. For example the expression of… CONTINUE READING

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