Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

@article{Niv2002ActivatedKA,
  title={Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells},
  author={Hagit Niv and Orit Gutman and Yoel Kloog and Yoav I. Henis},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={865 - 872}
}
Ras-membrane interactions play important roles in signaling and oncogenesis. H-Ras and K-Ras have nonidentical membrane anchoring moieties that can direct them to different membrane compartments. Ras-lipid raft interactions were reported, but recent studies suggest that activated K-Ras and H-Ras are not raft resident. However, specific interactions of activated Ras proteins with nonraft sites, which may underlie functional differences and phenotypic variation between different Ras isoforms, are… CONTINUE READING

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