Activated Galpha subunits can inhibit multiple signal transduction pathways during Dictyostelium development.

@article{Srinivasan1999ActivatedGS,
  title={Activated Galpha subunits can inhibit multiple signal transduction pathways during Dictyostelium development.},
  author={Jayashree Srinivasan and Robert E. Gundersen and J. A. Hadwiger},
  journal={Developmental biology},
  year={1999},
  volume={215 2},
  pages={
          443-52
        }
}
Mutations impairing the GTPase activity of G protein Galpha subunits can result in activated Galpha subunits that affect signal transduction and cellular responses and, in some cases, promote tumor formation. An analogous mutation in the Dictyostelium Galpha4 subunit gene (Q200L substitution) was constructed and found to inhibit Galpha4-mediated responses to folic acid, including the accumulation of cyclic nucleotides and chemotactic cell movement. The Galpha4-Q200L subunit also severely… CONTINUE READING
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