Activated Charcoal and Acetylcysteine Absorption: Issues in Interpreting Pharmacokinetic Data

@inproceedings{Wa1991ActivatedCA,
  title={Activated Charcoal and Acetylcysteine Absorption: Issues in Interpreting Pharmacokinetic Data},
  author={Watson Wa and McKinney Pe},
  year={1991}
}
  • Watson Wa, McKinney Pe
  • Published 1991
  • Chemistry
  • Studies determining the effects of activated charcoal on drug absorption frequently use area under the plasma drug concentration versus time curve or drug and metabolite recovery in the urine as endpoints. The considerations in using these endpoints is presented using studies that have evaluated the effects of activated charcoal on acetylcysteine absorption. Acetylcysteine's pharmacokinetics, quantitation of plasma concentrations, and the lack of an identifiable pharmacokinetic-pharmacodynamic… CONTINUE READING