Activated CD8(+) T cells from aged mice exhibit decreased activation-induced cell death.

@article{Hsu2001ActivatedCT,
  title={Activated CD8(+) T cells from aged mice exhibit decreased activation-induced cell death.},
  author={H C Hsu and Jishu Shi and P A Yang and Xin Xu and Christopher H Dodd and Yasunori Matsuki and Huang-ge Zhang and John D. Mountz},
  journal={Mechanisms of ageing and development},
  year={2001},
  volume={122 15},
  pages={1663-84}
}
To uncouple the defects of activation and apoptosis of T cells from aged mice, we used anti-CD3 plus IL-2 stimulation to induce an activation response and analyzed the subsequent activation-induced cell death (AICD) response of T cells from 16-month-old mice. The results herein demonstrate that T cells from 16-month-old mice could be activated by anti-CD3-induced activation signals but exhibited distinct phenotypic and functional features compared to young (2-month-old) mice. These include a… CONTINUE READING