Activated CD34-derived Langerhans cells mediate transinfection with human immunodeficiency virus.

@article{Fahrbach2007ActivatedCL,
  title={Activated CD34-derived Langerhans cells mediate transinfection with human immunodeficiency virus.},
  author={Kelly M. Fahrbach and Sheila M Barry and Seyoum Ayehunie and Sarah D K Lamore and Mitchell Klausner and Thomas J Hope},
  journal={Journal of virology},
  year={2007},
  volume={81 13},
  pages={6858-68}
}
Langerhans cells (LCs) are a subset of dendritic cells (DCs) that reside within epidermal and mucosal tissue. Because of their location, LCs are potentially the first cells to encounter human immunodeficiency virus (HIV) during sexual transmission. We report that LCs purified from CD34(+)-derived DCs can facilitate the transinfection of target cells but only after activation. Virions were observed in an intracellular compartment that contains several tetraspanins, in addition to the unique LC… CONTINUE READING
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