Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.

@article{Domingo2004ActivatedBT,
  title={Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.},
  author={Enric Domingo and Eloi Esp{\'i}n and Manel Armengol and Carla M Oliveira and Mafalda Pinto and A Duval and Caroline Brennetot and Raquel Seruca and Richard C Hamelin and Hiroyuki Yamamoto and Sim{\'o} Schwartz},
  journal={Genes, chromosomes & cancer},
  year={2004},
  volume={39 2},
  pages={138-42}
}
BRAF, a serine/threonine kinase of the RAF family, is a downstream transducer of the RAS-regulated MAPK pathway and signals upstream of MEK1/2 kinases. Recently, activating mutations within BRAF have been reported in a high percentage of melanomas and colorectal carcinomas and shown to have oncogenic capabilities. Further, their association to mismatch… CONTINUE READING