Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

  title={Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.},
  author={Shizhen Zhu and Jeong-Soo Lee and Feng Guo and Jimann Shin and Antonio R. Perez-Atayde and Jeffery L. Kutok and Scott J Rodig and Donna S Neuberg and Daniel Helman and Hui Feng and Rodney A Stewart and Wenchao Wang and Rani E. George and John P. Kanki and A Thomas Look},
  journal={Cancer cell},
  volume={21 3},
Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation of neuroblasts that migrate into the adrenal medulla… CONTINUE READING