Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration.

@article{Shi2011ActivatableAP,
  title={Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration.},
  author={Hui Shi and Xiaoxiao He and Kemin Wang and Xu Wu and Xiaosheng Ye and Qiuping P Guo and Weihong Tan and Zhihe Qing and Xiaohai Yang and Bing Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 10},
  pages={3900-5}
}
Aptamers have emerged as promising molecular probes for in vivo cancer imaging, but the reported "always-on" aptamer probes remain problematic because of high background and limited contrast. To address this problem, we designed an activatable aptamer probe (AAP) targeting membrane proteins of living cancer cells and achieved contrast-enhanced cancer visualization inside mice. The AAP displayed a quenched fluorescence in its free state and underwent a conformational alteration upon binding to… CONTINUE READING
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