Actions of tramadol on micturition in awake, freely moving rats.

@article{Pandita2003ActionsOT,
  title={Actions of tramadol on micturition in awake, freely moving rats.},
  author={Raj Kumar Pandita and Rikard Pehrson and Thomas Christoph and Elmar Friderichs and K -E Andersson},
  journal={British journal of pharmacology},
  year={2003},
  volume={139 4},
  pages={741-8}
}
1 (+/-)-Tramadol, a widely used analgesic, is a racemate stimulating opioid receptors and inhibiting reuptake of noradrenaline and serotonin, that is, pharmacological principles previously shown to influence rat micturition. 2 We studied both (+/-)-tramadol and its enantiomers in conscious Sprague-Dawley rats undergoing continuous cystometry. The effects of these agents were compared to those of morphine ( micro -opioid receptor agonist) and tested after pretreatment with naloxone ( micro… CONTINUE READING

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