Actions of thiocyanate and N-phenylmaleimide on volume-responsive Na and K transport in dog red cells.

@article{Parker1992ActionsOT,
  title={Actions of thiocyanate and N-phenylmaleimide on volume-responsive Na and K transport in dog red cells.},
  author={John Calvin Parker and G. Craig Colclasure},
  journal={The American journal of physiology},
  year={1992},
  volume={262 2 Pt 1},
  pages={
          C418-21
        }
}
Two sets of observations suggest a linkage between volume-responsive Na and K transport systems in dog red blood cells. 1) The lyotropic anion thiocyanate inhibits shrinkage-induced Na-H exchange and stimulates swelling-induced K-Cl cotransport. 2) The effect of a brief incubation with N-phenylmaleimide (NPM) on Na and K transport depends on the volume of the cells at the time of exposure to the sulfhydryl reagent. Cells shrunken during the NPM incubation and then brought back to normal volume… CONTINUE READING
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