Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors.

@article{Sattelle1989ActionsOT,
  title={Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors.},
  author={David B Sattelle and Steven Buckingham and Keith A Wafford and S M Sherby and N M Bakry and Amira T. Eldefrawi and Mohyee E. Eldefrawi and Tim E. May},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1989},
  volume={237 1289},
  pages={501-14}
}
The nitromethylene heterocyclic compound 2(nitromethylene)tetrahydro)1,3-thiazine (NMTHT) inhibits the binding of [125I]alpha-bungarotoxin to membranes prepared from cockroach (Periplaneta americana) nerve cord and fish (Torpedo californica) electric organ. Electrophysiological studies on the cockroach fast coxal depressor motorneuron (Df) reveal a dose-dependent depolarization in response to bath-applied NMTHT. Responses to ionophoretic application of NMTHT onto the cell-body membrane of… CONTINUE READING
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