Actions of synthetic parathyroid hormone-related protein(1-34) on the isolated rat kidney.

@article{Ebeling1989ActionsOS,
  title={Actions of synthetic parathyroid hormone-related protein(1-34) on the isolated rat kidney.},
  author={Peter R. Ebeling and William Robert Adam and Jane M. Moseley and Thomas J Martin},
  journal={The Journal of endocrinology},
  year={1989},
  volume={120 1},
  pages={45-50}
}
The isolated perfused rat kidney was used to study the effects of parathyroid hormone-related protein (PTHrP) on renal cyclic AMP (cAMP) and electrolyte excretion. A perfusate of PTHrP(1-34) increased cAMP excretion from 0.14 +/- 0.09 (S.E.M.) nmol/l glomerular filtrate (GF) in controls to 24.67 +/- 5.14 (P less than 0.01) and decreased calcium excretion from 0.278 +/- 0.033 to 0.162 +/- 0.011 mumol/l GF (P less than 0.01). Human PTH(1-34) (0.7 nmol/l) caused no significant change in calcium… CONTINUE READING

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