Actions of prostanoids to induce emesis and defecation in the ferret.

@article{Kan2002ActionsOP,
  title={Actions of prostanoids to induce emesis and defecation in the ferret.},
  author={Kelvin K. Kan and R. L. Jones and Man-Pui Ngan and John A Rudd},
  journal={European journal of pharmacology},
  year={2002},
  volume={453 2-3},
  pages={299-308}
}
Several prostanoids were investigated for their ability to induce emesis and/or defecation and tenesmus in the ferret. The rank order of emetic potency (dose producing four episodes, D4) was: sulprostone (5 microg/kg)>11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619; 8 microg/kg)>misoprostol (27 microg/kg)>17-phenyl-omega-trinor prostaglandin E2 (53 microg/kg)>prostaglandin E2 (94 microg/kg)>5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW245C; 148… CONTINUE READING