Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP

@article{Tseng1990ActionsOP,
  title={Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP},
  author={Gea -Ny Tseng and Brian F. Hoffman},
  journal={Pfl{\"u}gers Archiv},
  year={1990},
  volume={415},
  pages={414-424}
}
We studied the effects of pinacidil (3–50 μM) on the membrane currents of canine ventricular myocytes, using the whole-cell variant of the patch-clamp technique, and the modulation of these effects by intracellular environment, using the pipette perfusion technique. The following observations were obtained: (1) pinacidil induced a dosedependent outward shift in current at voltages positive to ±70 mV; (2) the pinacidil-induced current was largely timeindependent at voltages positive to ±50 mV… CONTINUE READING
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Modulation of ATPsensitive K channels in RINm 5 F cells by phosphorylation and G proteins

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Pinacidil - enhanced potassium currents in vascular smooth muscle are blocked by charybdotoxin

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