Actions of neurohypophysial peptides on pancreatic hormone release.

@article{Dunning1984ActionsON,
  title={Actions of neurohypophysial peptides on pancreatic hormone release.},
  author={Beth Elaine Dunning and J H Moltz and C. P. Fawcett},
  journal={The American journal of physiology},
  year={1984},
  volume={246 1 Pt 1},
  pages={E108-14}
}
The intermittent reports concerning metabolic actions of neurohypophysial extracts or hormones encouraged us to study the effect of these substances on the function of the endocrine pancreas. A surprisingly small amount of neural lobe (NL) extract (0.025 NL eq/ml) stimulated a 425% increase in the release of glucagon from islets isolated from the pancreas of the rat. Gel filtration of the extract produced an elution profile of glucagon-releasing activity that was superimposable on the profiles… CONTINUE READING

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