Actions of lofepramine, a new tricyclic antidepressant, and desipramine on electrophysiological and mechanical parameters of guinea pig atrial and papillary muscles.

  • Per Arlock
  • Published 1981 in Acta pharmacologica et toxicologica

Abstract

The effects of lofepramine on the isolated guinea pig atrial trabeculae were compared with those of desipramine. The preparations were taken from the same animal and mounted in the same tissue bath. All parameters were recorded in parallel. Lofepramine 10 microM was shown to exhibit minor changes in the transmembrane action potential duration only. The… (More)

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Cite this paper

@article{Arlock1981ActionsOL, title={Actions of lofepramine, a new tricyclic antidepressant, and desipramine on electrophysiological and mechanical parameters of guinea pig atrial and papillary muscles.}, author={Per Arlock}, journal={Acta pharmacologica et toxicologica}, year={1981}, volume={49 4}, pages={248-58} }