Actions of lipoproteins in cultured human mesangial cells: modulation by mitogenic vasoconstrictors.

@article{Grne1992ActionsOL,
  title={Actions of lipoproteins in cultured human mesangial cells: modulation by mitogenic vasoconstrictors.},
  author={Elisabeth F. Gr{\"o}ne and Hanna Emily Abboud and Marina Hoehne and Autar K. Walli and Hermann Josef Groene and Dietmar Stueker and Horst Robenek and Eberhard Wieland and Dietrich Seidel},
  journal={The American journal of physiology},
  year={1992},
  volume={263 4 Pt 2},
  pages={F686-96}
}
Recent studies have suggested that hypercholesterolemia may aggravate glomerulosclerosis. Mesangial cells actively participate in this process. To elucidate mechanisms by which lipids act on human mesangial cells (HMC), we measured the receptor-specific uptake of apolipoprotein (Apo) B- and Apo B- and E-containing lipoproteins in the presence and absence of growth factors and studied the growth-related mechanisms in HMC after exposure to low-density lipoprotein (LDL). Human LDL and very low… CONTINUE READING