Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones.

@article{MacDonald1991ActionsOK,
  title={Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones.},
  author={John F. MacDonald and M. Claire Bartlett and Istv{\'a}n M{\'o}dy and Peter A. Pahapill and James N. Reynolds and Michael W. Salter and Jacob H. Schneiderman and Peter S. Pennefather},
  journal={The Journal of physiology},
  year={1991},
  volume={432},
  pages={483-508}
}
1. Stable N-methyl-D-aspartic acid (NMDA) receptor-mediated currents in cultured mouse hippocampal neurons were evoked by 20 ms pressure pulse applications of L-aspartate, repeatedly applied at 30 or 40 s intervals, to the cell body region of the neurone. We have characterized the voltage- and use-dependent blockade of the currents by three dissociative anaesthetics: ketamine, phencyclidine (PCP) and MK-801 in mouse hippocampal neurones grown in dissociated tissue culture. 2. We have used a… CONTINUE READING

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