Actions of cholinergic agonists and antagonists on sensory nerve endings in rat skin, in vitro.

@article{Steen1993ActionsOC,
  title={Actions of cholinergic agonists and antagonists on sensory nerve endings in rat skin, in vitro.},
  author={Kay Hinrich Steen and Peter W Reeh},
  journal={Journal of neurophysiology},
  year={1993},
  volume={70 1},
  pages={397-405}
}
1. Cholinergic effects on primary sensory afferents were investigated in a superfused skin-saphenous nerve preparation of the rat that allows the application of chemicals topically to the corium side of identified receptive fields. 2. The acetylcholine analogue carbachol (carbamoylcholine) selectively excited cutaneous C-fibers of nociceptive character; in proportion, almost half of the mechanoheat sensitive ("polymodal," C-MH, n = 27), and a third of the mechanocold sensitive (C-MC, n = 10… CONTINUE READING