Corpus ID: 14672476

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

@article{Fredholm1999ActionsOC,
  title={Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.},
  author={B. Fredholm and K. B{\"a}ttig and J. Holm{\'e}n and A. Nehlig and E. Zvartau},
  journal={Pharmacological reviews},
  year={1999},
  volume={51 1},
  pages={
          83-133
        }
}
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For this 
View on PubMed
pharmrev.aspetjournals.org
2,251 Citations
Highly Influential Citations
260
Background Citations
991
Methods Citations
73
Results Citations
37

2,251 Citations

Citation Type

Citation Type

Behavioral Pharmacology of Caffeine
TLDR
The reviewed literature supports the concept that caffeine is a mild stimulant, reduces fatigue and plays a facilitatory role in working memory and this fully justifies its exclusion from the list of prohibited substances. Expand
Caffeine and the dopaminergic system
TLDR
An updated summary of the results reported in the literature concerning the behavioural pharmacology of caffeine and the neurochemical mechanisms underlying the psychostimulant effects elicited by caffeine is provided. Expand
[Caffeine--common ingredient in a diet and its influence on human health].
TLDR
It is underline that caffeine content in coffee and tea beverages varies greatly depending on the method of brewing whereas the content of caffeine in many brands of energy drinks can much vary, which should be taken into account in the daily caffeine intake. Expand
Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks
Caffeine (1,3,7-trimethylxanthine) is the most consumed psychoactive substance in the world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is the main natural source… Expand
Caffeine, mood and cognition.
: Caffeine is widely consumed and has widespread physiological effects. We review evidence that the acute alerting and associated psychomotor performance effects of caffeine experienced by frequent… Expand
Effects of caffeine in chewing gum on mood and attention
TLDR
Chewing gum has been shown to have behavioural effects and the present study extended the knowledge of this topic by giving caffeine in gum. Expand
Effects of caffeine in non‐withdrawn volunteers
TLDR
Using participants who had consumed their normal daily quota of caffeine this study alleviated this potential confound as all participants were not withdrawn at the time of testing. Expand
Behavioural effects of compounds co-consumed in dietary forms of caffeinated plants
TLDR
It is highlighted that more research aimed at understanding the effects of these compounds is needed and, more importantly, the synergistic relationship that they may have with caffeine. Expand
Caffeine & Health : Clarifying The Controversies IFIC
  • 2008
studied ingredients in the food supply. Yet, despite our considerable knowledge of caffeine and centuries of safe consumption in foods and beverages, questions and misperceptions about the potential… Expand
Coffee, Caffeine, and Health.
TLDR
This review summarizes the evidence about the varied physiological effects of caffeine and coffee in a large number of adults in many countries. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 602 REFERENCES
Effect of caffeine on coffee drinking
TLDR
This research indicates that coffee drinkers drink more low-caffeine coffee than non-decaffeinated coffee. Expand
Caffeine and health.
TLDR
The short-term physiological effects of caffeine are discussed and whether or not caffeine affects the risk of diseases such as cardiovascular disease and cancer, and its impact in special groups such as caffeine abusers is examined. Expand
THE EFFECT OF SMOKING ON CAFFEINE ELIMINATION: IMPLICATIONS FOR ITS USE AS A SEMIQUANTITATIVE TEST OF LIVER FUNCTION
1. The effects of caffeine ingestion and cigarette smoking on caffeine and antipyrine pharmacokinetics were studied using normal subjects as their own controls before and after cessation of smoking… Expand
The effects of caffeine.
  • I. Syed
  • Medicine
  • Journal of the American Pharmaceutical Association
  • 1976
TLDR
Evidence indicates that caffeine in moderation is safe, and can actually improve both mental and physical performance, and does not apply to children. Expand
The effect of dietary caffeine manipulation on blood caffeine, sleep and disturbed behaviour.
  • G. Searle
  • Psychology, Medicine
  • Journal of intellectual disability research : JIDR
  • 1994
TLDR
The effect of withdrawal of caffeine from the diet of a group of highly disturbed severely retarded adult patients was studied, and re-introduction of normal diet was accompanied by a highly significant increase in ward disturbance ratings. Expand
Caffeine: Clinical and experimental effects in humans
The contrast of attitudes to the psychiatric effects of caffeine between North America and Britain is highlighted. A summary of the dietary sources, pharmacology and effects of caffeine on normal… Expand
CAFFEINE WITHDRAWAL HEADACHE
  • R. Smith
  • Medicine
  • Journal of clinical pharmacy and therapeutics
  • 1987
TLDR
Failure to recognize the development of caffeine withdrawal symptoms can lead to clinical confusion, unnecessary investigations and regular consumption of caffeine-containing analgesics. Expand
The pharmacology of caffeine.
  • M. Arnaud
  • Medicine
  • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1987
TLDR
The pharmaceutical properties of caffeine described in this report explain its use in drugs used as stimulants, pain relievers, diuretics, cold remedies, weight control products, bronchial and cardiac stimulants as well as in drugs for the treatment of acne and other skin disorders. Expand
Caffeine alters plasma adenosine levels
TLDR
It is reported that caffeine increases plasmaAdenosine concentration in a manner that is dose-related, saturable, and mimicked by peripheral adenosine receptor blockade. Expand
Evidence for withdrawal from caffeine by rats
TLDR
Rats which had previously received injections of caffeine on each of twelve days avoided a novel solution which had been associated with the absence of caffeine and controls suggest that physiological withdrqwal from caffeine is the mechanism for this avoidance. Expand
...
1
2
3
4
5
...