• Corpus ID: 14672476

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

@article{Fredholm1999ActionsOC,
  title={Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.},
  author={Bertil B. Fredholm and Karl B{\"a}ttig and Jonathan Holm{\'e}n and Astrid Nehlig and E.E. Zvartau},
  journal={Pharmacological reviews},
  year={1999},
  volume={51 1},
  pages={
          83-133
        }
}
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For this 

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References

SHOWING 1-10 OF 595 REFERENCES
Effect of caffeine on coffee drinking
TLDR
This research indicates that coffee drinkers drink more low-caffeine coffee than non-decaffeinated coffee.
Caffeine and health.
  • C. Ashton
  • Medicine, Biology
    British medical journal
  • 1987
TLDR
The short-term physiological effects of caffeine are discussed and whether or not caffeine affects the risk of diseases such as cardiovascular disease and cancer, and its impact in special groups such as caffeine abusers is examined.
THE EFFECT OF SMOKING ON CAFFEINE ELIMINATION: IMPLICATIONS FOR ITS USE AS A SEMIQUANTITATIVE TEST OF LIVER FUNCTION
1. The effects of caffeine ingestion and cigarette smoking on caffeine and antipyrine pharmacokinetics were studied using normal subjects as their own controls before and after cessation of smoking
The effects of caffeine.
  • I. Syed
  • Medicine
    Journal of the American Pharmaceutical Association
  • 1976
Caffeine: Clinical and experimental effects in humans
TLDR
The case is made for the inclusion of a specific category, in non‐dependent abuse of drugs, for caffeine in normal subjects, and a more specific evaluation of the psychiatric issues are discussed.
The effect of dietary caffeine manipulation on blood caffeine, sleep and disturbed behaviour.
  • G. Searle
  • Medicine, Psychology
    Journal of intellectual disability research : JIDR
  • 1994
TLDR
The effect of withdrawal of caffeine from the diet of a group of highly disturbed severely retarded adult patients was studied, and re-introduction of normal diet was accompanied by a highly significant increase in ward disturbance ratings.
The pharmacology of caffeine.
  • M. Arnaud
  • Medicine
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1987
TLDR
The pharmaceutical properties of caffeine described in this report explain its use in drugs used as stimulants, pain relievers, diuretics, cold remedies, weight control products, bronchial and cardiac stimulants as well as in drugs for the treatment of acne and other skin disorders.
Caffeine alters plasma adenosine levels
TLDR
It is reported that caffeine increases plasmaAdenosine concentration in a manner that is dose-related, saturable, and mimicked by peripheral adenosine receptor blockade.
Evidence for withdrawal from caffeine by rats
The analgesic effects of caffeine in headache
...
...