• Corpus ID: 14672476

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

  title={Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.},
  author={Bertil B. Fredholm and Karl B{\"a}ttig and Jonathan Holm{\'e}n and Astrid Nehlig and E.E. Zvartau},
  journal={Pharmacological reviews},
  volume={51 1},
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For this 

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