Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma.

@article{Yoneda2000ActionsOB,
  title={Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma.},
  author={Toshiyuki Yoneda and Toshimi Michigami and Bing Yi and Paul J. Williams and Maryla Niewolna and Toru Hiraga},
  journal={Cancer},
  year={2000},
  volume={88 12 Suppl},
  pages={2979-88}
}
BACKGROUND Bone, which abundantly stores a variety of growth factors, provides a fertile soil for cancer cells to develop metastases by supplying these growth factors as a consequence of osteoclastic bone resorption. Accordingly, suppression of osteoclast activity is a primary approach to inhibit bone metastasis, and bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used for the treatment of bone metastases in cancer patients. To obtain further insights into the… CONTINUE READING

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