Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit composition

@article{Harris1995ActionsOA,
  title={Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit composition},
  author={R. Adron Harris and S John Mihic and Jo Ellen Dildy-Mayfield and Tina K. Machu},
  journal={The FASEB Journal},
  year={1995},
  volume={9},
  pages={1454 - 1462}
}
Molecular cloning of cDNAs coding for ligand‐gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of agents that produce general anesthesia. We review the effects of volatile and intravenous anesthetics on recombinant GABAa, glycine, AMPA, kainate, NMDA, and 5HT3 receptors. Evidence for and against specific ligand‐gated ion channel subunits as… Expand
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