Actions of a polypeptide toxin from the marine snail Conus striatus on voltage-sensitive sodium channels.

@article{Gonoi1987ActionsOA,
  title={Actions of a polypeptide toxin from the marine snail Conus striatus on voltage-sensitive sodium channels.},
  author={T Gonoi and Yasushi Ohizumi and Jun'ichi Kobayashi and Hitomi Nakamura and William A. Catterall},
  journal={Molecular pharmacology},
  year={1987},
  volume={32 5},
  pages={691-8}
}
The effects of a polypeptide toxin of 25,000 Da from the marine snail Conus striatus (CsTx) on sodium channels in mouse neuroblastoma cells and rat brain synaptosomes were studied. CsTx slowed sodium channel inactivation without altering the time course of activation of the channels. The voltage dependence of sodium channel inactivation was shifted to more negative membrane potentials and made less steep. Peak sodium currents were increased, and the voltage dependence of activation was shifted… CONTINUE READING

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