Actions of General Anesthetics on Acetylcholine Receptor-rich Membranes from Torpedo californica

@article{Firestone1986ActionsOG,
  title={Actions of General Anesthetics on Acetylcholine Receptor-rich Membranes from Torpedo californica},
  author={L. Firestone and J. -F. Sauter and Leon M. Braswell and Keith W Miller},
  journal={Anesthesiology},
  year={1986},
  volume={64},
  pages={694-702}
}
The molecular mechanisms by which general anesthetics act on postsynaptic membranes can only be worked out in a highly purified, homogeneous system. The nicotinic acetylcholine receptor-rich membranes from the electric tissue of Torpedo californica are currently the only postsynaptic membranes that fulfill this condition. Is this peripheral synapse acted on with a pharmacologic specificity similar to that for general anesthesia, and how much less sensitive is it to anesthetic action than the… Expand
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