Actions of CRF and its analogs.

  title={Actions of CRF and its analogs.},
  author={Klaus Eckart and Jelena Radulovic and Marko Radulovic and Olaf Jahn and Thomas E. Blank and Oliver Stiedl and Joachim Spiess},
  journal={Current medicinal chemistry},
  volume={6 11},
Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CRFR2. The latter exists as two splice variants, the neuronal CRFR2a and the peripheral CRFR2b. CRFR is a G protein-dependent receptor which acts mainly through Gs enhancing cAMP production. However, CRFR1 expressed in neutrophils of the spleen in response to immunologic stimulation and psychological… CONTINUE READING


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