Actions of 5α-reductase inhibitors on the epididymis

@article{Robaire2006ActionsO5,
  title={Actions of 5$\alpha$-reductase inhibitors on the epididymis},
  author={Bernard Robaire and Natali Anne Henderson},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={250},
  pages={190-195}
}
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39 Citations
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11
Methods Citations
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39 Citations

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Androgen and oestrogen modulation by D-aspartate in rat epididymis.
TLDR
The results suggest that D-Asp modulates androgen and oestrogen levels and expression of androgens and Oestrogen receptors in the rat epididymis by acting on the expression of 5α-red and P450-aro genes.
Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines.
TLDR
A radiosubstrate in vitro incubation method for the determination of 5alpha-reductase type 1 activity using rat liver microsomes as an enzyme source is developed and results provide interesting structure-activity relationship data.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.
TLDR
It is demonstrated that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation.
The Effect of Different Doses of Finasteride on Epididymis and Testosterone and DHT Concentrations in Rats
TLDR
It is evident from the results that there is a need for further clarification of the relation between finasteride administration and specific parameters in epididymal functions if administered in high dose.
The expression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of rats with a dihydrotestosterone (DHT) deficiency
TLDR
The data clearly indicates that a finasterideinduced DHT deficiency intensifies the constitutive expression of iNOS in most rat testicular and epididymal cells, so it can be expected that the expression of inducible nitric oxide synthase (iNOS) could be regulated by DHT.
Testosterone undecanoate in the functional compartments of the male reproductive tract
TLDR
It is concluded that TU was identified and measured for the first time in seminal plasma of a fair percentage of men on this medication and was associated in all men with a marked rise of DHT concentration, a known epididymal function promoter, in the absence of an effect on pituitary and gonadal activity.
Expression and regulation of FAAP in the mouse epididymis
TLDR
It is demonstrated thatFAAP mRNA and protein expression are highly regionalized in the mouse epididymis with predominant enrichment in the initial segment and that expression of the FAAP mRNA is highly dependent on the presence of luminal testicular factors rather than testosterone.
Influence of antifertility agents Dutasteride and Nifedipine on CatSper gene level in epididymis during sperm maturation in BALB/c mice.
TLDR
It is observed that treatment with antifertility agents Dutasteride and Nifedipine induced significant decreases in the caput and cauda epididymal sperm counts, motility and fertility which could partly be attributed to alteration in the normal morphology of the sperm associated with downregulation/upregulation of CatSper mRNAs in epididyl spermatozoa of male BALB/c mice.
Post-finasteride syndrome☆☆☆
Rat epididymal epithelial cells and 17beta-estradiol synthesis under hCG stimulation in vitro.
TLDR
The present studies show the organelles which take part in synthesis of steroids in rat epididymal epithelial cells in vitro and the effect of hCG on E2 synthesis.
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References

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Effects of PNU 157706 , a dual 5-reductase inhibitor , on gene expression in the rat epididymis
TLDR
A dual 5 -reductase inhibitor and cDNA microarrays are employed to examine the effects of 5 - reductase inhibition on gene expression in the initial segment, caput, corpus, and cauda epididymidis to provide a novel insight into the DHT-dependent mechanisms that control epidIDymal functions.
Effects of PNU157706, a dual 5alpha-reductase inhibitor, on gene expression in the rat epididymis.
TLDR
A dual 5alpha-reductase inhibitor and cDNA microarrays are employed to provide a novel insight into the DHT-dependent mechanisms that control epididymal functions and the effect of treatment on gene expression was dose-dependent and highly segment-specific.
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The effect of finasteride in BPH was proven in clinical studies and the circulating and intraprostatic DHT could be further reduced by a more effective dual 5-alpha-reductase inhibitor, which would be efficacious in the treatment of benign prostate hyperplasia and other DHT-related disorders.
Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility1
TLDR
A role for dual 5α-reductase inhibitors in further studies of epididymal physiology and as a potential component of a male contraceptive is indicated.
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TLDR
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TLDR
It was found that spermatozoa from the distal corpus which were already capable of fertilizing eggs prior to the cultures retain this ability for 1 day without addition of hormone and for 3–4 days when testosterone or 5α-dihydrotestosterone is added to the culture medium.
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TLDR
Results indicate that PNU 157706 is a promising, potent inhibitor of both type II and I human 5alpha-R with a very marked antiprostatic effect in the rat.
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