Actions of 5α-reductase inhibitors on the epididymis

  title={Actions of 5α-reductase inhibitors on the epididymis},
  author={B. Robaire and N. Henderson},
  journal={Molecular and Cellular Endocrinology},
  • B. Robaire, N. Henderson
  • Published 2006
  • Biology
  • Molecular and Cellular Endocrinology
  • Abstract Testosterone is converted to the more biologically active androgen, dihydrotestosterone (DHT), by steroid 5α-reductase. Two isozymes of 5α-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa. Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation. Several compounds have been reported to inhibit either one or both forms of 5… CONTINUE READING
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