• DOI:10.1016/j.mce.2005.12.044
Corpus ID: 53464391

Actions of 5α-reductase inhibitors on the epididymis

@article{Robaire2006ActionsO5,
  title={Actions of 5α-reductase inhibitors on the epididymis},
  author={B. Robaire and N. Henderson},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={250},
  pages={190-195}
}

B. Robaire, N. Henderson

Published 2006

Biology

Molecular and Cellular Endocrinology

Abstract Testosterone is converted to the more biologically active androgen, dihydrotestosterone (DHT), by steroid 5α-reductase. Two isozymes of 5α-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa. Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation. Several compounds have been reported to inhibit either one or both forms of 5… CONTINUE READING

View on Elsevier

forum.propeciahelp.com

Save to Library

Create Alert

Cite

Launch Research Feed