Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

@article{NewmanTancredi1998ActionsO,
  title={Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors},
  author={Adrian Newman-Tancredi and J.-P. Nicolas and Val{\'e}rie Audinot and Samantha Gavaudan and Laurence Verri{\`e}le and Manuelle Touzard and Christine J Chaput and Nad{\`e}ge Richard and Mark John Millan},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1998},
  volume={358},
  pages={197-206}
}
This study examined the activity of chemically diverse α2 adrenoceptor ligands at recombinant human (h) and native rat (r) α2A adrenoceptors as compared with 5-HT1A receptors. First, in competition binding experiments at hα2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (±)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for hα2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Autoradiographic studies of central α 2 A and α 2 B adrenoceptors in the rat using [ 3 H ] MK 912 and subtype - selective drugs

S Uhlén, Wikberg JES
Brain Res • 1997

The role of descending noradrenergic and serotoninergic pathways in the modulation of nociception : focus on receptor multiplicity

MJ Millan
1997

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