Actions mediated by P2-purinoceptor subtypes in the isolated perfused mesenteric bed of the rat.

@article{Ralevic1988ActionsMB,
  title={Actions mediated by P2-purinoceptor subtypes in the isolated perfused mesenteric bed of the rat.},
  author={Vera Ralevic and Geoffrey Burnstock},
  journal={British journal of pharmacology},
  year={1988},
  volume={95 2},
  pages={637-45}
}
1. The effects of adenosine 5'-triphosphate (ATP) and its analogues on the perfusion pressure of the isolated mesenteric bed of the rat were examined in preparations at resting tone, and with tone raised by noradrenaline. 2. In the preparations at resting tone, the effect of the analogues was to produce vasoconstriction, their rank order of potency being alpha,beta-methylene ATP greater than 2-methylthio ATP greater than ATP. 3. In raised tone preparations, dose-dependent vasodilatations were… CONTINUE READING
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