Corpus ID: 35277614

Actions and addiction liabilities of alpha-acetyl-methadols in man.

@article{Fraser1952ActionsAA,
  title={Actions and addiction liabilities of alpha-acetyl-methadols in man.},
  author={H. F. Fraser and H. Isbell},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1952},
  volume={105 4},
  pages={
          458-65
        }
}
1. dl-, d- and l -Alpha-acetylmethadol possess addiction liability. 2. Single subcutaneous or intravenous doses of d -alpha-acetylmethadol in former morphine addicts promptly induced a train of morphine-like effects which disappeared in less than 24 hours. Oral administration of d -alpha-acetyl-methadol was less efficacious than subcutaneous or intravenous administration. 3. Definite morphine-like effects did not appear for four to six hours after subcutaneous or intravenous injections of l… Expand
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