Action sites of antiallergic drugs on human neutrophils.

@article{Taniguchi1990ActionSO,
  title={Action sites of antiallergic drugs on human neutrophils.},
  author={K. Taniguchi and Y. Masuda and K. Takanaka},
  journal={Japanese journal of pharmacology},
  year={1990},
  volume={52 1},
  pages={
          101-8
        }
}
Sites of the inhibitory action of antiallergic drugs (azelastine, oxatomide, tranilast, repirinast and amlexanox) on human neutrophils were investigated by measuring leukotriene B4 formation, arachidonic acid release and superoxide generation. Results obtained in this study were as follows: (i) Formations of leukotriene B4 by neutrophils activated with a calcium ionophore (A23187) were effectively inhibited by all types of antiallergic drugs examined here, although the required concentrations… Expand
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