Action potentials reliably invade axonal arbors of rat neocortical neurons.

  title={Action potentials reliably invade axonal arbors of rat neocortical neurons.},
  author={Charles L. Cox and Winfried Denk and David W. Tank and Karel Svoboda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 17},
Neocortical pyramidal neurons have extensive axonal arborizations that make thousands of synapses. Action potentials can invade these arbors and cause calcium influx that is required for neurotransmitter release and excitation of postsynaptic targets. Thus, the regulation of action potential invasion in axonal branches might shape the spread of excitation in cortical neural networks. To measure the reliability and extent of action potential invasion into axonal arbors, we have used two-photon… CONTINUE READING
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