Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channels

@article{Burdyga2005ActionPR,
  title={Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channels},
  author={Theodor V. Burdyga and Susan Wray},
  journal={Nature},
  year={2005},
  volume={436},
  pages={559-562}
}
In excitable tissues the refractory period is a critical control mechanism preventing hyperactivity and undesirable tetani, by preventing subsequent stimuli eliciting action potentials and Ca2+ entry. In ureteric smooth muscle, peristaltic waves that occur as invading pacemaker potentials produce long-lasting action potentials (300–800 ms) and extraordinarily long (more than 10 s) refractory periods, which prevent urine reflux and kidney damage. For smooth muscles neither the mechanisms… CONTINUE READING

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the case for loose coupling

  • Kotlikoff, M. I. Calcium-induced calcium release in smooth muscle
  • Prog. Biophys. Mol. Biol. 83, 171–-191
  • 2003

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