Action of theophylline on secretagogue-stimulated amylase release from dispersed pancreatic acini.

@article{Korman1980ActionOT,
  title={Action of theophylline on secretagogue-stimulated amylase release from dispersed pancreatic acini.},
  author={L. Korman and M. Walker and J. Gardner},
  journal={The American journal of physiology},
  year={1980},
  volume={239 4},
  pages={
          G324-G333
        }
}
In dispersed acini from guinea pig pancreas, theophylline did not alter basal amylase release, but had three functionally distinct modes of action on the stimulation of amylase release caused by various secretagogues. 1) At relatively low concentrations (0.1-1.0 mM), theophylline augmented the increase in enzyme secretion caused by vasoactive intestinal peptide, secretin, or 8-bromoadenosine 3',5'-monophosphate, but did not alter the increase in amylase release caused by other secretagogues. 2… Expand
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